The Least Appreciated Aspect of Testosterone Optimization


Sophrosyne newsletter

The Least Appreciated Aspect of Testosterone Optimization?

The Butterfly-Shaped Gland: Your Thyroid

Today, I'm going to explain the necessity for optimizing your Thyroid health as a man.

I aim to cover;

  • A general overview
  • Why it's crucial for the synthesis of Testosterone
  • Hyperthyroidism & hypothyroidism symptoms
  • How to determine your Thyroid hormone function
  • Bulletproof ways to ensure Thyroid health

Oftentimes, men who seek remedies in a clinical Testosterone Replacement Therapy (TRT) setting, simply require tweaks to optimize their Thyroid function.

In other words, low Testosterone symptoms can be solved in many cases by optimizing the gentlemen's Thyroid health.

This gets them back to sufficient natural Testosterone levels, without medical intervention.

This stuff is low-hanging fruit guys.

Let's get into it.

A Quick Overview

So what is the Thyroid?

The Thyroid is a small, butterfly-shaped gland located in your neck.

Its main role is regulating energy expenditure and metabolism.

However, the Thyroid has many other functions and features; including sexual function, bone density, and heart health.

If you've been following my content for a while now, you'll know that Testosterone is primarily synthesized through the Hypothalamus-Pituitary-Gonad (HPG) Axis.

  • The Hypothalamus releases Gonadotropin Releasing Hormone (GnRH)
  • GnRH signals to our Pituitary to release our Gonadotropins; Luteinizing Hormone (LH) & Follicle Stimulating Hormone (FSH)
  • LH signals to our Leydig cells to produce Testosterone

The Hypothalamus also releases Thyroid Releasing Hormones (TRH).

  • The Hypothalamus releases TRH
  • The release of TRH signals to our Pituitary to release Thyroid Stimulating Hormones (TSH)
  • TSH signals to our Thyroid to release T3 & T4 Thyroid Hormones

Testosterone Synthesis?

The T3 Thyroid hormone - Triiodothyronine - is the bioavailable one.

It's heavily involved in the synthesis of Testosterone.

Here's a synopsis of its involvement;

  • T3 regulates Sex Hormone Binding Globulin (SHBG) production in the liver

SHBG binds to our bioavailable, Free Testosterone, which is technically the most important because it carries out the gene transcription once it docks to our Androgen Receptors. This interaction is what allows you to experience the marvels of Testosterone.

  • Thyroid Releasing Hormones (TH) are involved in Prolactin regulation

Prolactin and Testosterone tend to work inversely. As Prolactin spikes, Testosterone dips.

  • T3 increases Testosterone

The T3 Thyroid hormone also boosts important enzymes - such as Steroidogenic Acute Regulatory Protein (StAR) - in the Testosterone cascade.

StAR boosts the conversion of Cholesterol to Pregnenolone. These are two precursors of Testosterone.

  • T3 improves Gonadotropin Releasing Hormone (GnRH) sensitivity

Luteinizing Hormone (LH) signals to our testes to make Testosterone. The T3 Thyroid Hormone increases the body's response to LH, by increasing the number of LH receptors.

As you can see, Thyroid health is crucial for optimal Testosterone production.

But what happens if we neglect the Thyroid?

Hyperthyroidism VS Hypothyroidism

There are two undesirable Thyroid situations; hyperthyroidism and hypothyroidism.

Hyperthyroidism is a condition where the Thyroid is working in overdrive.

It can be caused by Grave's disease, other autoimmunity issues, and internal Thyroid inflammation.

Hyperthyroidism impacts Testosterone through;

  • Potential Hyperprolactinemia (excessive Prolactin secretion)
  • High SHBG (SHBG binds to our Free Testosterone)
  • Low Free Testosterone (our bioavailable form)
  • Slaughtered sperm health
  • High Aromatization (conversion of Testosterone to Estrogen)

Symptoms of Hyperthyroidism include;

  • Jitters
  • Hair loss
  • Inability to focus
  • Sleep issues
  • Rapid weight loss
  • Goiter (swollen thyroid gland)
  • Bulging eyes

On the flip side, Hypothyroidism is an underactive Thyroid gland. It can be caused by Iodine deficiencies or autoimmune conditions.

Hypothyroidism impacts Testosterone through;

  • Low SHBG AND low Free Testosterone (usually inverse)
  • Lower Total Testosterone
  • Low Gonadotropin production; LH & FSH
  • High Prolactin

Symptoms include;

  • Inability to put on, and maintain muscle
  • Swollen Thyroid
  • Lethargy
  • Fertility issues
  • Anxiety

How Do You Know If Your Thyroid Is Functioning Properly?

If you find yourself experiencing any of the above consequences/symptoms, it may be worth doing a blood panel to test your Thyroid Hormones.

It's a very simple process.

You can either;

  1. Go to your local GP and get them to organize it.
  2. Order an online at-home test kit.

Both are easy and worth doing.

However, optimizing your lifestyle so that the below tactics are adopted will ensure some level of Thyroid health.

The Fundamentals of Thyroid Optimization

  1. Buffer Against Chronic Stress

Chronic stress is a silent killer.

It drives our biologically programmed alarm system - Cortisol - to undesirable levels.

Excessive Cortisol production can put strain on our Pituitary gland, which distorts Thyroid hormone production - remember that Thyroid Stimulating Hormones (TSH) are released from our Pituitary gland.

Chronic stress can essentially shift the Thyroid into an inactive state.

Some Cortisol modulation basics are;

  • Parasympathetic breathwork practices
  • Exposure to the natural world (beaches, forests, parks etc)
  • Slow-wave Binaural beats (alpha, theta, and delta waves)
  • Dialed in sleep
  • Dietary Omega 3s and supplemental L-Theanine

I wrote an entire newsletter on managing chronic stress. You can read it here if you like.

2. Prioritize L-Tyrosine, Selenium & Choline

There is a growing cohort of people online promoting micros > macros.

It's a justified position to take, given the current state of food and nutrition.

It's no secret that food is less nutrient dense nowadays, due to modern farming practices, environmental toxins, and herbicides.

This is why prioritizing micronutrient intake in this modern ecosystem is so vital.

There are three essential micronutrients for Thyroid hormone production;

  1. L-Tyrosine

L-Tyrosine is a naturally occurring Amino Acid, involved in the synthesis of Dopamine.

It's also involved in the production of T3 & T4 Thyroid hormones.

The best sources of L-Tyrosine include;

  • Red meat
  • Eggs
  • Dairy products
  • Option to supplement too.

2. Selenium

Selenium is an important mineral that allows L-Tyrosine and Iodine (below) to interact, and thus produce Thyroid hormones.

The best sources include;

  • Organ meats
  • Brazil nuts
  • Tuna
  • Option to supplement too.

3. Iodine

Iodine is a trace element required for the production of T3 & T4 Thyroid Hormones.

The best sources include;

  • Iodized salt
  • Seaweed
  • Shellfish
  • Option to supplement too.

My dietary strategy for getting all three of these micronutrients is a small serving of beef liver with some iodized salt on top. The liver is L-Tyrosine and Selenium rich, and the Iodized salt is Iodine rich.

3. Cold Water

The dreaded cold shower.

Yes, cold water is brutal - especially if you're lean - but it is fantastic for the burning of brown fat, and the stimulation of Thyroid Hormones.

Every morning I take a cold shower, but there's initial resistance.

I often bark, shout, and shadowbox in the mirror to get myself gee'd up for it.

Legit me before I get in:

Cold water is tricky, but it has a massive antidepressant effect on me - I feel a million bucks after I get out.

I recommend you do the same if you don't already.

4. High-Octane Light

When I say high-octane light, I'm referring to natural sunlight or certain artificial Infrared wavelengths.

Sunlight should be the priority, but Infrared panels are fantastic too.

These are the panels I'm referring to:

The majority of Thyroid issues stem from some distorted immune response - think Grave's Disease & Hashimoto's Disease.

Sunlight, and specifically Vitamin D, assist with the regulation and function of your immune system which further assists with Thyroid health.

Vitamin D deficiencies and insufficiencies have been linked to Thyroid cancer and Thyroid autoimmunity.

Aim to get natural sunlight through your eyes and on the skin in the early AM, noon and evening.

5. Gut Health

This ties into the previous section.

A distorted immune response can be amplified or caused by a leaky gut.

Addressing your gut health holistically is the best path forward;

  1. Kefir, Sauerkraut, Raw Cheese, Kombucha and Gherkins.
  2. Natural sunlight or infrared panels
  3. Dietary pre & probiotics: Yoghurt, Onions, Garlic & Bananas
  4. Beef liver
  5. Apple skins: digestion triggers the growth of a helpful microbe called Akkermansia. Apple skins produce 8 times more Akkermansia than any other source.
  6. Circadian balance: dialed in sleep schedule

6. Metabolic Activity

The human organism is mostly sedentary nowadays, which is in direct opposition to our nature.

You need to be prioritizing some form of movement daily.

It can be as strenuous as a leg day in the gym, or as laid-back as a post-meal walk.

Just move more.

Synopsis

If you're still reading at this point, I thank you dearly - we've covered a lot.

This newsletter was written to help you understand the Thyroid gland and its necessity for men's health.

We went through a quick overview of the Thyroid, and its main role - energy expenditure.

We also covered the Thyroid's role in the production of Testosterone, and how to measure your Thyroid hormones.

The T3 Thyroid hormone;

  • Regulates SHBG
  • Increases Testosterone
  • Boosts Luteinizing Hormone sensitivity
  • Manages Prolactin levels

Finally, I listed six Thyroid health basics;

  • Manage Cortisol
  • Prioritize L-Tyrosine, Selenium & Iodine
  • Daily cold water exposure
  • Daily high-octane light exposure
  • Address gut health holistically
  • Stay metabolically active (move more)

I hope I have demonstrated the necessity for Thyroid health as a man.

It truly is the least appreciated aspect of Testosterone optimization.

I wish you well on your journey brother!

Until next time.

PS, my Twitter DMs are always open if you have any questions.

Did you enjoy this email?

Jack, from Sophrosyne

113 Cherry St #92768, Seattle, WA 98104-2205
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